Anti-Matriptase 2/TMPRSS6 Antibody Picoband®

SKU: A02093-1

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: ELISA,Flow Cytometry,WB

Application Details: Western blot, 0.25-0.5 μg/ml, Human, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/ml, -

Gene Name: TMPRSS6

Specificity:

Background: Transmembrane protease, serine 6 (also known as matriptase-2) is an enzyme that in humans is encoded by the TMPRSS6 gene. The protein encoded by this gene is a type II transmembrane serine proteinase that is found attached to the cell surface. The encoded protein may be involved in matrix remodeling processes in the liver. Alternative splicing results in multiple transcript variants.

Immunogen: E.coli-derived human Matriptase 2/TMPRSS6 recombinant protein (Position: M1-Q759).

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Du, X., She, E., Gelbart, T., Truksa, J., Lee, P., Xia, Y., Khovananth, K., Mudd, S., Mann, N., Moresco, E. M. Y., Beutler, E., Beutler, B. The serine protease TMPRSS6 is required to sense iron deficiency. Science 320: 1088-1092, 2008. 2. Finberg, K. E., Heeney, M. M., Campagna, D. R., Aydinok, Y., Pearson, H. A., Hartman, K. R., Mayo, M. M., Samuel, S. M., Strouse, J. J., Markianos, K., Andrews, N. C., Fleming, M. D. Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA). Nature Genet. 40: 569-571, 2008. 3. Guillem, F., Kannengiesser, C., Oudin, C., Lenoir, A., Matak, P., Donadieu, J., Isidor, B., Mechinaud, F., Aguilar-Martinez, P., Beaumont, C., Vaulont, S., Grandchamp, B., Nicolas, G. Inactive matriptase-2 mutants found in IRIDA patients still repress hepcidin in a transfection assay despite having lost their serine protease activity. Hum. Mutat. 33: 1388-1396, 2012.

Uniprot ID: Q8IU80

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 90 kDa, 95 kDa

Calculated Molecular Weight:

Gene ID: 164656

Protein Name: Transmembrane protease serine 6

Gene Full Name: transmembrane serine protease 6

Synonyms: IRIDA; Matriptase 2; TMPRSS6