Anti-Mannose Receptor/MRC1 Picoband® Antibody

SKU: A02285-2

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human,Monkey,Mouse,Rat

Applications: ELISA,IF,IHC,WB

Application Details: Western blot, 0.25-0.5μg/ml, Human, Monkey, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 2-5μg/ml, Human, Mouse, Rat
Immunofluorescence, 5 μg/ml, Human, Mouse
ELISA, 0.1-0.5μg/ml, -

Gene Name: MRC1

Specificity: No cross reactivity with other proteins.

Background: The mannose receptor (Cluster of Differentiation 206, CD206) is a C-type lectin primarily present on the surface of macrophages, immature dendritic cells and liver sinusoidal endothelial cells, but is also expressed on the surface of skin cells such as human dermal fibroblasts and keratinocytes. It is mapped to 10p12.33. The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.

Immunogen: E.coli-derived human Mannose Receptor/MRC1 recombinant protein (Position: D21-A1140).

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Eichbaum, Q., Clerc, P., Bruns, G., McKeon, F., Ezekowitz, R. A. B. Assignment of the human macrophage mannose receptor gene (MRC1) to 10p13 by in situ hybridization and PCR-based somatic cell hybrid mapping. Genomics 22: 656-658, 1994. 2. Harris, N., Peters, L. L., Eicher, E. M., Rits, M., Raspberry, D., Eichbaum, Q. G., Super, M., Ezekowitz, R. A. B. The exon-intron structure and chromosomal localization of the mouse macrophage mannose receptor gene, Mrc1: identification of a ricin-like domain at the N-terminus of the receptor. Biochem. Biophys. Res. Commun. 198: 682-692, 1994. 3. Kim, S. J., Ruiz, N., Bezouska, K., Drickamer, K. Organization of the gene encoding the human macrophage mannose receptor (MRC1). Genomics 14: 721-727, 1992.

Uniprot ID: P22897

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate: This is the unconjugated antibody. It is also available with 10 conjugation options, including Biotin, Cy3, Fluoro488, Fluoro550, Fluoro594, FITC, HRP, APC, PE, and Fluoro647. A carrier-free (BSA-free) version is also available. Additional charges may apply for some options. Please contact us for a quote

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 190-200 kDa

Calculated Molecular Weight: 75694 MW

Gene ID: 4360

Protein Name: Peptidyl-prolyl cis-trans isomerase FKBP1A/1B

Gene Full Name: mannose receptor C-type 1

Synonyms: CD206; CLEC13D; Macrophage mannose receptor 1; Mannose receptor; mannose receptor; C type 1; MMR; MRC1