Anti-KCNA6 Antibody Picoband®

SKU: A11084-1

Size: 100 μg

Storage: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: WB,IHC,Flow Cytometry

Application Details: Western blot, 0.25-0.5 μg/ml, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/ml, Human, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human

Gene Name: KCNA6

Specificity:

Background: Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class. The coding region of this gene is intronless, and the gene is clustered with genes KCNA1 and KCNA5 on chromosome 12.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human KCNA6. Human KCNA6 shares 100% and 95.2% amino acid (aa) sequence identity with mouse and rat KCNA6, respectively.

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Albrecht, B., Weber, K., Pongs, O. Characterization of a voltage-activated K-channel gene cluster on human chromosome 12p13. Receptors Channels 3: 213-220, 1995. 2. Chandy, K. G., Williams, C. B., Spencer, R. H., Aguilar, B. A., Ghanshani, S., Tempel, B. L., Gutman, G. A. A family of three mouse potassium channel genes with intronless coding regions. Science 247: 973-975, 1990. 3. Grupe, A., Schroter, K. H., Ruppersberg, J. P., Stocker, M., Drewes, T., Beckh, S., Pongs, O. Cloning and expression of a human voltage-gated potassium channel: a novel member of the RCK potassium channel family. EMBO J. 9: 1749-1756, 1990.

Uniprot ID: P17658

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 59 kDa

Calculated Molecular Weight: 59 kDa

Gene ID: 3742

Protein Name: Potassium voltage-gated channel subfamily A member 6

Gene Full Name: potassium voltage-gated channel subfamily A member 6

Synonyms: Protein Phosphatase 1; Regulatory Subunit 96; PPP1R96; Potassium voltage-gated channel subfamily A member 6; Kv1.6; Human Brain Potassium Channel-2