Anti-JAK3 Antibody Picoband®

SKU: A02598-3

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human

Applications: ELISA,WB

Application Details: Western blot, 0.1-0.5μg/ml
ELISA, 0.1-0.5μg/ml

Gene Name: JAK3

Specificity: No cross reactivity with other proteins.

Background: Tyrosine-protein kinase JAK3 is an enzyme that in humans is encoded by the JAK3 gene. It is mapped to 19p13.11. The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease).

Immunogen: E.coli-derived human JAK3 recombinant protein (Position: Q406-D661).

Clonality: Polyclonal

Contents: Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Riedy MC, Dutra AS, Blake TB, Modi W, Lal BK, Davis J, Bosse A, O'Shea JJ, Johnston JA (October 1996). Genomic sequence, organization, and chromosomal localization of human JAK3. Genomics. 37 (1): 57–61. 2. Hoffman SM, Lai KS, Tomfohrde J, Bowcock A, Gordon LA, Mohrenweiser HW (July 1997). JAK3 maps to human chromosome 19p12 within a cluster of proto-oncogenes and transcription factors. Genomics. 43 (1): 109–11.

Uniprot ID: P52333

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate: This is the unconjugated antibody. It is also available with 10 conjugation options, including Biotin, Cy3, Fluoro488, Fluoro550, Fluoro594, FITC, HRP, APC, PE, and Fluoro647. A carrier-free (BSA-free) version is also available. Additional charges may apply for some options. Please contact us for a quote

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 125 kDa

Calculated Molecular Weight:

Gene ID: 3718

Protein Name: Tyrosine-protein kinase JAK3

Gene Full Name: Janus kinase 3

Synonyms: Janus kinase 3; JAK-3_HUMAN; JAKL; L-JAK; LJAK; JAK3