Anti-IQCE Antibody Picoband®

SKU: A13989-1

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: WB,ICC,IF,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/ml, Human
ELISA, 0.1-0.5 μg/ml, -

Gene Name: IQCE

Specificity:

Background: IQ domain-containing protein E is a protein that in humans is encoded by the IQCE gene. Chromosome 7 is about 158 milllion bases long, encodes over 1000 genes and makes up about 5?% of the human genome. Chromosome 7 has been linked to Osteogenesis imperfecta, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome. The deletion of a portion of the q arm of chromosome 7 is associated with Williams-Beuren syndrome, a condition characterized by mild mental retardation, an unusual comfort and friendliness with strangers and an elfin appearance. Deletions of portions of the q arm of chromosome 7 are also seen in a number of myeloid disorders including cases of acute myelogenous leukemia and myelodysplasia.

Immunogen: E.coli-derived human IQCE recombinant protein (Position: D112-H621). Human IQCE shares 67.1% amino acid (aa) sequence identity with mouse IQCE.

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Estrada-Cuzcano, A., Etard, C., Delvallee, C., Stoetzel, C., Schaefer, E., Scheidecker, S., Geoffroy, V., Schneider, A., Studer, F, Mattioli, F., Chennen, K., Sigaudy, S., Plassard, D., Poch, O., Piton, A., Strahle, U., Muller, J., Dollfus, H. Novel IQCE variations confirm its role in postaxial polydactyly and cause ciliary defect phenotype in zebrafish. Hum. Mutat. 41: 240-254, 2020. 2. Kikuno, R., Nagase, T., Ishikawa, K., Hirosawa, M., Miyajima, N., Tanaka, A., Kotani, H., Nomura, N., Ohara, O. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 6: 197-205, 1999. 3. Pusapati, G. V., Hughes, C. E., Dorn, K. V., Zhang, D., Sugianto, P., Aravind, L., Rohatgi, R. EFCAB7 and IQCE regulate Hedgehog signaling by tethering the EVC-EVC2 complex to the base of primary cilia. Dev. Cell 28: 483-496, 2014.

Uniprot ID: Q6IPM2

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity:

Isotype: IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 72 kDa

Calculated Molecular Weight:

Gene ID: 23288

Protein Name: IQ domain-containing protein E

Gene Full Name: IQ motif containing E

Synonyms: IQCE; KIAA1023; IQ domain-containing protein E