Anti-Human CD19 Reference Antibody (Coltuximab, RUO)

SKU: HB996016

Size:100ug

Description:Coltuximab ravtansine (SAR3419) is an antibody-drug conjugate (ADC) targeting CD19 created by conjugating a derivative of the potent microtubule-acting cytotoxic agent, maytansine, to a version of the anti-CD19 antibody, anti-B4, that was humanized as an IgG1 by variable domain resurfacing. Four different linker-maytansinoid constructs were synthesized (average ∼3.5 maytansinoids/antibody for each) to evaluate the impact of linker-payload design on the activity of the maytansinoid-ADCs targeting CD19. Anti-CD19 humanized monoclonal antibody conjugated to DM4.

Host species:Chimeric

Tested applications:

Species reactivity:Human

Form:Liquid

Storage buffer:0.01M PBS, pH 7.4.

Purity:>95% as determined by SDS-PAGE.

Clonality:Monoclonal

Isotype:IgG1-kappa

Applications:ELISA, Bioactivity: FACS, Functional assay, Research in vivo

Target:CD19, Differentiation antigen CD19, T-cell surface antigen Leu-12, B-lymphocyte antigen CD19, B-lymphocyte surface antigen B4

Purification:Protein A/G purified from cell culture supernatant.

Endotoxin level:Please contact us for this information.

Expression system:Mammalian Cells

Accession:P15391

Stability and Storage:Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Reconstitution:

Background:

Alternative Names:SAR3419, 1269764-99-9

Clone ID:

Species:Human

Note:For research use only. Not suitable for clinical or therapeutic use.