Anti-GIMAP5 Antibody Picoband®

SKU: A07653-2

Size: 100 μg

Storage: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human,Rat

Applications: WB,ICC/IF,IP,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Human, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/ml, Human
Immunoprecipitation, 0.5-2 μg/ml, Human
ELISA, 0.1-0.5 μg/ml

Gene Name: GIMAP5

Specificity:

Background: This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. This gene encodes an antiapoptotic protein that functions in T-cell survival. Polymorphisms in this gene are associated with systemic lupus erythematosus. Read-through transcription exists between this gene and the neighboring upstream GIMAP1 (GTPase, IMAP family member 1) gene.

Immunogen: E.coli-derived human GIMAP5 recombinant protein (Position: M1-E240). Human GIMAP5 shares 61.7% and 57.9% amino acid (aa) sequence identity with mouse and rat GIMAP5, respectively.

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Barnes, M. J., Aksoylar, H., Krebs, P., Bourdeau, T., Arnold, C. N., Xia, Y., Khovananth, K., Engel, I., Sovath, S., Lampe, K., Laws, E., Saunders, A., Butcher, G. W., Kronenberg, M., Steinbrecher, K., Hildeman, D., Grimes, H. L., Beutler, B., Hoebe, K. Loss of T cell and B cell quiescence precedes the onset of microbial flora-dependent wasting disease and intestinal inflammation in Gimap5-deficient mice. J. Immun. 184: 3743-3754, 2010. 2. Daheron, L., Zenz, T., Siracusa, L. D., Brenner, C., Calabretta, B. Molecular cloning of Ian4: a BCR/ABL-induced gene that encodes an outer membrane mitochondrial protein with GTP-binding activity. Nucleic Acids Res. 29: 1308-1316, 2001. 3. Drzewiecki, K., Choi, J., Brancale, J., Leney-Greene, M. A., Sari, S., Dalgic, B., Aksu, A. U., Sahin, G. E., Ozen, A., Baris, S., Karakoc-Aydiner, E., Jain, D., and 10 others. GIMAP5 maintains liver endothelial cell homeostasis and prevents portal hypertension. J. Exp. Med. 218: e20201745, 2021.

Uniprot ID: Q96F15

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 35 kDa

Calculated Molecular Weight: 35 kDa

Gene ID: 55340

Protein Name: GTPase IMAP family member 5

Gene Full Name: GTPase, IMAP family member 5

Synonyms: GIMAP5, GTPase IMAP family member 5, GTPase, IMAP family member 5, hIAN5, HIMAP3, IAN 5, IAN4, IAN4L1, IAN5, IMAP3, Immunity associated protein 3