Anti-GAB2 Antibody Picoband®

SKU: A02386-3

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human,Mouse

Applications: WB,Flow Cytometry,ELISA

Application Details: Western blot, 0.1-0.25 μg/ml, Human, Rat
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/ml, -

Gene Name: GAB2

Specificity:

Background: GRB2-associated-binding protein 2 also known as GAB2 is a protein that in humans is encoded by the GAB2 gene. This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene

Immunogen: E.coli-derived human GAB2 recombinant protein (Position: S162-R504).

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Bentires-Alj, M., Gil, S. G., Chan, R., Wang, Z. C., Wang, Y., Imanaka, N., Harris, L. N., Richardson, A., Neel, B. G., Gu, H. A role for the scaffolding adapter GAB2 in breast cancer. Nature Med. 12: 114-121, 2006. 2. Chapuis, J., Hannequin, D., Pasquier, F., Bentham, P., Brice, A., Leber, I., Frebourg, T., Deleuze, J.-F., Cousin, E., Thaker, U., Amouyel, P., Mann, D., Lendon, C., Campion, D., Lambert, J.-C. Association study of the GAB2 gene with the risk of developing Alzheimer's disease. Neurobiol. Dis. 30: 103-106, 2008. 3. Gu, H., Saito, K., Klaman, L. D., Shen, J., Fleming, T., Wang, Y.-P., Pratt, J. C., Lin, G., Lim, B., Kinet, J.-P., Neel, B. G. Essential role for Gab2 in the allergic response. Nature 412: 186-190, 2001.

Uniprot ID: Q9UQC2

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 90 kDa

Calculated Molecular Weight:

Gene ID: 9846

Protein Name: GRB2-associated-binding protein 2

Gene Full Name: GRB2 associated binding protein 2

Synonyms: GAB2; GRB2 associated binder 2; KIAA0571; pp100