Anti-FOXC1 Antibody Picoband®

SKU: A00962-2

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human

Applications: ELISA,IF,ICC,WB

Application Details: Western blot, 0.1-0.25μg/ml, Human
Immunocytochemistry/Immunofluorescence, 5 μg/ml, Human
ELISA, 0.1-0.5μg/ml, -

Gene Name: FOXC1

Specificity: No cross reactivity with other proteins.

Background: Forkhead box C1, also known as?FOXC1, is a?protein?which in humans is encoded by the?FOXC1?gene. It is mapped to 6p25.3. This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly.

Immunogen: E.coli-derived human FOXC1 recombinant protein (Position: T392-F554).

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Pierrou S, Hellqvist M, Samuelsson L, Enerbäck S, Carlsson P (October 1994). Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending. The EMBO Journal. 13 (20): 5002–12. 2. Nishimura DY, Swiderski RE, Alward WL, Searby CC, Patil SR, Bennet SR, Kanis AB, Gastier JM, Stone EM, Sheffield VC (June 1998). The forkhead transcription factor gene FKHL7 is responsible for glaucoma phenotypes which map to 6p25. Nature Genetics. 19 (2): 140–7. 3. Kume T, Jiang H, Topczewska JM, Hogan BL (September 2001). The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis. Genes & Development. 15 (18): 2470–82. doi:10.1101/gad.907301.

Uniprot ID: Q12948

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate: This is the unconjugated antibody. It is also available with 10 conjugation options, including Biotin, Cy3, Fluoro488, Fluoro550, Fluoro594, FITC, HRP, APC, PE, and Fluoro647. A carrier-free (BSA-free) version is also available. Additional charges may apply for some options. Please contact us for a quote

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 75 kDa

Calculated Molecular Weight: 53 kDa

Gene ID: 2296

Protein Name: Forkhead box protein C1

Gene Full Name: forkhead box C1

Synonyms: ARA; FKHL7; forkhead box C1; Forkhead box protein C1; Forkhead related protein FKHL7; FOXC1; FREAC 3; FREAC3; IGDA; IHG1; IRID1; RIEG3