Anti-Flu A (H3N2) HA/Hemagglutinin Broadly Neutralizing Reference Antibody (CR8020)

SKU: VK515096

Size:100ug

Description:CR8020 is a broadly neutralizing antibody (bNAb) targeting the stem region of influenza A virus (IAV) hemagglutinin (HA) and is in phase II trials for prophylactic use against group 2 IAVs. Structural and computational analyses show that CR8020 binds HA residues subject to antigenic drift and host selection pressure, with escape mutations observed in some H7N9 strains. Additionally, effective engagement of Fcγ receptors (FcγR) is crucial for antibody efficacy, but membrane steric hindrance may limit HA-CR8020-FcγR complex formation. These findings highlight epitope mutability and immune complex accessibility as key factors in bNAb development.

Host species:Human

Tested applications:

Species reactivity:Influenza A virus (strain A/Hong Kong/1/1968 H3N2)

Form:Liquid

Storage buffer:0.01M PBS, pH 7.4.

Purity:>95% purity as determined by SDS-PAGE.

Clonality:

Isotype:IgG1-lambda

Applications:ELISA, Bioactivity: FACS, Functional assay, Research in vivo

Target:Hemagglutinin, Hemagglutinin HA1 chain, Hemagglutinin HA2 chain, HA

Purification:Protein A/G purified from cell culture supernatant.

Endotoxin level:Please contact us for this information.

Expression system:Mammalian Cells

Accession:Q91MA7

Stability and Storage:Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.

Reconstitution:

Background:

Alternative Names:

Clone ID:CR8020

Species:

Note:For research use only. Not suitable for clinical or therapeutic use.