Anti-Fgf19(Fgf15) Antibody

SKU: PB10062

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Mouse,Rat

Applications: IHC

Application Details: Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/ml, Mouse, Rat

Gene Name: Fgf19(Fgf15)

Specificity: No cross reactivity with other proteins.

Background: FGF15/19 refers to two orthologous fibroblast growth factors which share 50% aminoacid identity and have similar functions. FGF15 was described in the mouse; FGF19 was found in humans and other species. They share physiological functions and so are often referred to as FGF15/19 or as FGF15/FGF19. They were first described in developing fetal brain. They are now known to be produced in the ileum, and under certain circumstances in the liver and biliary tree. It is thought their principal function is in response to bile acid absorption occurring after meals. FGF15 and FGF19 have similar roles in regulating bile acid synthesis and also glucose metabolism in the liver.

Immunogen: E. coli-derived rat Fgf19(Fgf15) recombinant protein (Position: R26-K218). Rat Fgf19(Fgf15) shares 53.2% and 96.4% amino acid (aa) sequence identity with human and mouse FGF19, respectively.

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Jones, SA (2012). Physiology of FGF15/19. Advances in Experimental Medicine and Biology. 728: 171–82. 2. Potthoff, MJ; Kliewer, SA; Mangelsdorf, DJ (2012). Endocrine fibroblast growth factors 15/19 and 21: from feast to famine. Genes & Development. 26 (4): 312–324. 3. Owen, BM; Mangelsdorf, DJ; Kliewer, SA (January 2015). Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21. Trends in Endocrinology and Metabolism. 26 (1): 22–9.

Uniprot ID: Q8VI81

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate: This is the unconjugated antibody. It is also available with 10 conjugation options, including Biotin, Cy3, Fluoro488, Fluoro550, Fluoro594, FITC, HRP, APC, PE, and Fluoro647. A carrier-free (BSA-free) version is also available. Additional charges may apply for some options. Please contact us for a quote

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 24 kDa

Calculated Molecular Weight: 24003 MW

Gene ID: 170582/14170

Protein Name: Fibroblast growth factor

Gene Full Name: fibroblast growth factor 19

Synonyms: FGF 19; FGF19; fibroblast growth factor 19