Anti-Factor V/F5 Antibody Picoband®

SKU: A00440-1

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human

Applications: WB

Application Details: Western blot,0.1-0.5μg/ml

Gene Name: F5

Specificity: No cross reactivity with other proteins.

Background: Factor V is a protein of the coagulation system, rarely referred to as proaccelerin or labile factor. The gene for factor V is located on the first chromosome (1q23). This gene encodes an essential cofactor of the blood coagulation cascade. This factor circulates in plasma, and is converted to the active form by the release of the activation peptide by thrombin during coagulation. This generates a heavy chain and a light chain which are held together by calcium ions. The activated protein is a cofactor that participates with activated coagulation factor X to activate prothrombin to thrombin. Defects in this gene result in either an autosomal recessive hemorrhagic diathesis or an autosomal dominant form of thrombophilia, which is known as activated protein C resistance.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human Factor V.

Clonality: Polyclonal

Contents: Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Bertina RM, Koeleman BP, Koster T, Rosendaal FR, Dirven RJ, de Ronde H, van der Velden PA, Reitsma PH (May 1994). Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature. 369 (6475): 64–7. 2. Nicolaes GA, Dahlbäck B (April 2002). Factor V and thrombotic disease: description of a janus-faced protein. Arteriosclerosis, Thrombosis, and Vascular Biology. 22 (4): 530–8.

Uniprot ID: P12259

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate: This is the unconjugated antibody. It is also available with 10 conjugation options, including Biotin, Cy3, Fluoro488, Fluoro550, Fluoro594, FITC, HRP, APC, PE, and Fluoro647. A carrier-free (BSA-free) version is also available. Additional charges may apply for some options. Please contact us for a quote

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 252 kDa

Calculated Molecular Weight:

Gene ID: 2153

Protein Name: Coagulation factor V

Gene Full Name: coagulation factor V

Synonyms: Activated protein C cofactor; Coagulation factor V; F5; FVL; PCCF; Proaccelerin; labile factor