Anti-DR6/TNFRSF21 Antibody Picoband®

SKU: A04348-2

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: WB,IHC,Flow Cytometry

Application Details: Western blot, 0.25-0.5μg/ml, Human, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 2-5μg/ml, Human
Flow Cytometry (Fixed), 1-3μg/1x10⁶ cells, Human

Gene Name: TNFRSF21

Specificity:

Background: This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human DR6/TNFRSF21, which shares 84.2% amino acid (aa) sequence identity with both mouse and rat DR6/TNFRSF21.

Clonality: Polyclonal

Contents: Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg NaN3.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Gross, M. B. Personal Communication. Baltimore, Md. 12/2/2019. 2. Mi, S., Lee, X., Hu, Y., Ji, B., Shao, Z., Yang, W., Huang, G., Walus, L., Rhodes, K., Gong, B. J., Miller, R. H., Pepinsky, R. B. Death receptor 6 negatively regulates oligodendrocyte survival, maturation and myelination. Nature Med. 17: 816-821, 2011. 3. Nikolaev, A., McLaughlin, T., O'Leary, D. D. M., Tessier-Lavigne, M. APP binds DR6 to trigger axon pruning and neuron death via distinct caspases. Nature 457: 981-989, 2009.

Uniprot ID: O75509

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 80-120 kDa

Calculated Molecular Weight:

Gene ID: 27242

Protein Name: Tumor necrosis factor receptor superfamily member 21

Gene Full Name: TNF receptor superfamily member 21

Synonyms: TNF receptor superfamily member 21; BM-018; CD358; DR6; TNFRSF21