Anti-Dopamine Receptor D3/DRD3 Antibody Picoband®

SKU: PA1584

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: IHC,WB

Application Details: Western blot, 0.1-0.5μg/ml, Human, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 2-5μg/ml, Human, Rat

Gene Name: DRD3

Specificity: No cross reactivity with other proteins.

Background: DRD3 is a dopamine receptor that differs in its pharmacology and signaling system from the D1 and D2 receptors and represents both an autoreceptor and a postsynaptic receptor. DRD3 is localized to limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. The DRD3 gene, which is mapped to chromosome 3, is like the DRD2 gene but unlike most other members of this superfamily and it contains introns, 5 in number. The position of 2 of the introns corresponds to that of introns in DRD2. The D3 receptor appeared to mediate some of the effects of antipsychotic drugs and drugs used in the treatment of Parkinson disease, which were previously though to interact only with D2 receptors.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Dopamine Receptor D3, different from the related rat and mouse sequences by two amino acids.

Clonality: Polyclonal

Contents: Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg NaN3.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Sokoloff, P., Giros, B., Martres, M.-P., Bouthenet, M.-L., Schwartz, J.-C.Molecular cloning and characterization of a novel dopamine receptor (D-3) as a target for neuroleptics.Nature 347: 146-151, 1990. 2. Le Coniat, M., Sokoloff, P., Hillion, J., Martres, M.-P., Giros, B., Pilon, C., Schwartz, J.-C., Berger, R.Chromosomal localization of the human D-3 dopamine receptor gene.Hum. Genet. 87: 618-620, 1991. 3. Sokoloff, P., Giros, B., Martres, M.-P., Bouthenet, M.-L., Schwartz, J.-C.Molecular cloning and characterization of a novel dopamine receptor (D-3) as a target for neuroleptics.Nature 347: 146-151, 1990.

Uniprot ID: P35462

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 59 kDa

Calculated Molecular Weight: 44 kDa

Gene ID: 1814

Protein Name: D

Gene Full Name: dopamine receptor D3

Synonyms: Dopamine Receptor D3; Dopamine D3 receptor; DRD3; ETM1; FET1