Anti-CCDC115 Antibody Picoband®

SKU: A13807-1

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human

Applications: WB,IHC,ICC,IF,Flow Cytometry,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Human
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/ml, Human
Immunocytochemistry/Immunofluorescence, 5 μg/ml, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/ml, -

Gene Name: CCDC115

Specificity:

Background: Coiled-coil domain containing 115 is a protein that in humans is encoded by the CCDC115 gene. The protein encoded by this gene has been observed to localize to the endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC) and coat protein complex I (COPI) vesicles in some human cells. The encoded protein shares some homology with the yeast V-ATPase assembly factor Vma22p, and the orthologous protein in mouse promotes cell proliferation and suppresses cell death. Defects in this gene are a cause of congenital disorder of glycosylation, type IIo in humans.

Immunogen: E.coli-derived human CCDC115 recombinant protein (Position: M1-A180).

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. D., Krawitz, P., Wada, Y., Ashikov, A., Perez-Cerda, C., and 31 others. CCDC115 deficiency causes a disorder of Golgi homeostasis with abnormal protein glycosylation. Am. J. Hum. Genet. 98: 310-321, 2016. 2. Pellicano, F., Inglis-Broadgate, S. L., Pante, G., Ansorge, W., Iwata, T. Expression of coiled-coil protein 1, a novel gene downstream of FGF2, in the developing brain. Gene Expr. Patterns 6: 285-293, 2006. 3. Pellicano, F., Thomson, R. E., Inman, G. J., Iwata, T. Regulation of cell proliferation and apoptosis in neuroblastoma cells by ccp1, a FGF2 downstream gene. BMC Cancer 10: 657, 2010. Note: Electronic Article.

Uniprot ID: Q96NT0

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 20 kDa

Calculated Molecular Weight: 64099 MW

Gene ID: 84317

Protein Name: Vacuolar ATPase assembly protein VMA22

Gene Full Name: vacuolar ATPase assembly factor VMA22

Synonyms: CCDC115; ccp1