Anti-ADRM1/ARM-1 Antibody Picoband®

SKU: A04010-2

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: WB,IHC,ICC,IF,Flow Cytometry,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Human, Mouse, Rat
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/ml, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/ml, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/ml, -

Gene Name: ADRM1

Specificity:

Background: Proteasomal ubiquitin receptor ADRM1 is a protein that in humans is encoded by the ADRM1 gene. This gene encodes a member of the adhesion regulating molecule 1 protein family. The encoded protein is a component of the proteasome where it acts as a ubiquitin receptor and recruits the deubiquitinating enzyme, ubiquitin carboxyl-terminal hydrolase L5. Increased levels of the encoded protein are associated with increased cell adhesion, which is likely an in effect of this intracellular protein. Dysregulation of this gene has been implicated in carcinogenesis. Alternative splicing results in multiple transcript variants.

Immunogen: E.coli-derived human ADRM1/ARM-1 recombinant protein (Position: S15-K390).

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Husnjak, K., Elsasser, S., Zhang, N., Chen, X., Randles, L., Shi, Y., Hofmann, K., Walters, K. J., Finley, D., Dikic, I. Proteasome subunit Rpn13 is a novel ubiquitin receptor. Nature 453: 481-488, 2008. 2. Jorgensen, J. P., Lauridsen, A.-M., Kristensen, P., Dissing, K., Johnsen, A. H., Hendil, K. B., Hartmann-Petersen, R. Adrm1, a putative cell adhesion regulating protein, is a novel proteasome-associated factor. J. Molec. Biol. 360: 1043-1052, 2006. 3. Lamerant, N., Kieda, C. Adhesion properties of adhesion-regulating molecule 1 protein on endothelial cells. FEBS J. 272: 1833-1844, 2005.

Uniprot ID: Q16186

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 42 kDa

Calculated Molecular Weight: 23310 MW

Gene ID: 11047

Protein Name: Proteasomal ubiquitin receptor ADRM1

Gene Full Name: ADRM1 26S proteasome ubiquitin receptor

Synonyms: adhesion regulating molecule 1; ADRM1; ARM 1; ARM1; GP110; hRpn13; Rpn13; Rpn13 homolog