Anti-ABCB6 Antibody Picoband®

SKU: PA1723

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human

Applications: IHC,ICC,WB

Application Details: Immunocytochemistry , 0.5-1μg/ml, Human, -
Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human
Western blot, 0.1-0.5μg/ml, Human

Gene Name: ABCB6

Specificity: No cross reactivity with other proteins.

Background: ABCB6, ATP-binding cassette sub-family B member 6, mitochondrialis a protein that in humans is encoded by the ABCB6 gene. The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This half-transporter likely plays a role in mitochondrial function. Localized to 2q26, this gene is considered a candidate gene for lethal neonatal metabolic syndrome, a disorder of mitochondrial function.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human ABCB6.

Clonality: Polyclonal

Contents: Each vial contains antibody formulated with stabilizing components, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
*This antibody is supplied in a stabilized formulation. Compatibility with conjugation reactions depends on the chemistry of the conjugation method used. For conjugation methods that are not compatible with the stabilizing components present in this formulation, a carrier-free antibody format is required.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Helias, V., Saison, C., Ballif, B. A., Peyrard, T., Takahashi, J., Takahashi, H., Tanaka, M., Deybach, J.-C., Puy, H., Le Gall, M., Sureau, C., Pham, B.-N., Le Pennec, P.-Y., Tani, Y., Cartron, J.-P., Arnaud, L.ABCB6 is dispensable for erythropoiesis and specifies the new blood group system Langereis.Nature Genet. 44: 170-173, 2012. 2. Krishnamurthy, P. C., Du, G., Fukuda, Y., Sun, D., Sampath, J., Mercer, K. E., Wang, J., Sosa-Pineda, B., Murti, K. G., Schuetz, J. D.Identification of a mammalian mitochondrial porphyrin transporter.Nature 443: 586-589, 2006. 3. Wang, L., He, F., Bu, J., Liu, X., Du, W., Dong, J., Cooney, J. D., Dubey, S. K., Shi, Y., Gong, B., Li, J., McBride, P. E., and 11 others.ABCB6 mutations cause ocular coloboma.Am. J. Hum. Genet. 90: 40-48, 2012.

Uniprot ID: Q9NP58

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 94 kDa

Calculated Molecular Weight: 93886 MW

Gene ID: 10058

Protein Name: ATP-binding cassette sub-family B member 6

Gene Full Name: ATP binding cassette subfamily B member 6 (LAN blood group)

Synonyms: ABC; ABC14; ABCB6, EST45597; Mt ABC transporter 3; MTABC3; P glycoprotein related protein; PRP; umat