AMPKα2 rabbit pAb

SKU: ES20835

Size: 100μL

Source:Rabbit

Applications:WB

Reactivity:Human;Mouse;Rat

Dilution:WB: 1:1000-2000

Immunogen:Recombinant Protein of AMPKα2

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:

Observed_band(KD):62kD

Human_gene_id:5563

Human_swiss_prot_no:P54646

Subcellular_location:Cytoplasm . Nucleus . In response to stress, recruited by p53/TP53 to specific promoters. .

Other_name:PRKAA2; AMPK; AMPK2; 5'-AMP-activated protein kinase catalytic subunit alpha-2; AMPK subunit alpha-2; Acetyl-CoA carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase

Background:The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008],