ALPL Monoclonal Antibody

SKU: BT-MCA3985

Size:100μL

Background:There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described.

Research_area:Cell Biology

Target_protein:ALPL

applications:WB, IHC, FCM

Reactivity:Human

Clonality:Monoclonal

Clone ID:2F4

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:ALPL

Immunogen:Purified recombinant fragment of human ALPL expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):57.3kDa

UniProt accession:P05186

Synonyms:HOPS, TNAP, APTNAP, TNSALP, AP-TNAP

GeneID:249