ALKBH8 Antibody - Cat. #: CSB-PA842644ESR2HU

SKU: CSB-PA842644ESR2HU

Size :50ul

Clone Number:

Aliases:4930562C03Rik antibody; 8030431D03Rik antibody; 9430088N01Rik antibody; ABH8 antibody; alkB alkylation repair homolog 8 (E. coli) antibody; alkB alkylation repair homolog 8 antibody; AlkB homologue 8 antibody; ALKB8_HUMAN antibody; ALKBH8 antibody; Alkylated DNA repair protein alkB homolog 8 antibody; FLJ38204 antibody; MGC10235 antibody; OTTHUMP00000211286 antibody; OTTHUMP00000211287 antibody; Probable alpha-ketoglutarate-dependent dioxygenase ABH8 antibody; RGD1304687 antibody; S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8 antibody; tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q96BT7

Immunogen:Recombinant Human Alkylated DNA repair protein alkB homolog 8 protein (1-230AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain (PubMed:20123966, PubMed:20308323). Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA (PubMed:20123966, PubMed:20308323). Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys)(PubMed:20308323). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly) (PubMed:21285950). Required for normal survival after DNA damage (PubMed:20308323). May inhibit apoptosis and promote cell survival and angiogenesis (PubMed:19293182).

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen Affinity purified

Conjugate:Non-conjugated

Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:ALKBH8

Research Areas:Epigenetics and Nuclear Signaling; Cancer