ALKBH1 Antibody - Cat. #: CSB-PA199021

SKU: CSB-PA199021

Size :50ul

Clone Number:

Aliases:ABH antibody; ABH1 antibody; alkB antibody; alkB homolog 1 histone H2A dioxygenase antibody; AlkB; alkylation repair homolog 1 (E. coli) antibody; ALKB1_HUMAN antibody; ALKBH antibody; ALKBH1 antibody; Alkylated DNA repair protein alkB homolog 1 antibody; Alkylation repair homolog 1 antibody; Alkylation repair; alkB homolog antibody; Alpha-ketoglutarate-dependent dioxygenase ABH1 antibody; DNA lyase ABH1 antibody; DNA oxidative demethylase ALKBH1 antibody; hABH antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q13686

Immunogen:Fusion protein of Human ALKBH1

Raised in:Rabbit

Species Reactivity:Human, Mouse

Tested Applications:ELISA, WB; ELISA:1:2000-1:5000, WB:1:500-1:2000

Background:This gene encodes a homolog to the E. coli alkB gene product. The E. coli alkB protein is part of the adaptive response mechanism of DNA alkylation damage repair. It is involved in damage reversal by oxidative demethylation of 1-methyladenine and 3-methylcytosine. Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast lineage differentiation. Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen affinity purification

Conjugate:Non-conjugated

Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:ALKBH1

Research Areas:Epigenetics and Nuclear Signaling