ALK/p80 Monoclonal Antibody

SKU: BT-MCA2568

Size:100μL

Background:This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).

Research_area:Others

Target_protein:ALK/p80

applications:FCM

Reactivity:

Clonality:Monoclonal

Clone ID:7D6A2

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:ALK/p80

Immunogen:Purified recombinant fragment of human ALK/p80 (AA: 1359-1460) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):176.4kDa

UniProt accession:Q9UM73

Synonyms:CD246, NBLST3

GeneID:238