Afutuzumab ELISA Kit

SKU: DY257028

Size:96T

Applications:ELISA

Accession:P11836

Stability and Storage:The stability of ELISA kit is determined by the loss rate of activity. The loss rate of this kit is less than 10% prior to the expiration date under appropriate storage condition.

Detection method:Colorimetric

Sample type:Plasma, Serum

Assay type:Quantitative

Sensitivity:0.156 μg/ml

Range:0.31-5 μg/mL

Recovery:80-120%

Properties:

Experimental Procedure:

Background:Afutuzumab is a monoclonal antibody that targets the CD20 antigen expressed on the surface of pre-B and mature B lymphocytes. Upon binding to CD20, obinutuzumab mediates B-cell lysisthrough (1) engagement of immune effector cells (2) by directly activating intracellular death signaling pathways (direct cell death), and/or (3) activation of the complement cascade. The immune effector cell mechanisms include antibody-dependent cellular cytotoxicity (ADCC) and antibodydependent cellular phagocytosis.As an antibody with reduced fucose content, obinutuzumab induces greater ADCC activity than rituximab in vitro using human cancer cell lines. Afutuzumab also demonstrated an increased ability to induce direct cell death when compared to rituximab. Afutuzumab binds to FcγRIII using purified proteins with a higher affinity than rituximab. Afutuzumab and rituximab bind with similar affinity to overlapping epitopes on CD20.

Alternative Names:GA101, RG7159, RO5072759, 949142-50-1

Shipping:2-8 ℃

Note:For Research Use Only.