ACTα2 Polyclonal Antibody

SKU: D-AB-10442L

Size::25μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:ACTα2

Target Synonym:Actin;aortic smooth muscle;Alpha-actin-2;Actin;aortic smooth muscle;intermediate form;Acta2;Actsa;Actvs

Research Areas:Immunology;Neuroscience;Stem Cells

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human

Application:WB

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:P62737

Accession:

Background:alpha-2-macroglobulin,also known as α2-macroglobulin(α2M and A2M),is an abundant protein of the plasma of vertebrates and members of several invertebrate phyla and functions as a broad-spectrum protease-binding protein. alpha-2-macroglobulin is produced by the liver,and is a major component of the alpha-2 band in protein electrophoresis. alpha-2-macroglobulin is a large plasma glycoprotein that has long been known as an irreversible inhibitor of a variety of proteinases. More recently,it has been reported that numerous growth factors,cytokines and hormones bind to alpha 2M through diverse mechanisms. A2M is also produced in the brain where it binds multiple extracellular ligands and is internalized by neurons and astrocytes. In the brain of Alzheimer's disease (AD) patients,A2M has been localized to diffuse amyloid plaques. A2M also binds soluble beta-amyloid,of which it mediates degradation. Protease-conjugated alpha2-macroglobulin is selectively bound by cells contacting the body fluids and alpha2-macroglobulin and its protease cargo are then internalized and degraded in secondary lysosomes of those cells. In addition to this function as an agent for protease clearance,alpha2-macroglobulin binds a variety of other ligands,including several peptide growth factors and modulates the activity of a lectin-dependent cytolytic pathway in arthropods.

Concentration:1 mg/mL

Immunogen:Recombinant Mouse ACTα2 protein expressed by E.coli

Buffer:PBS with 0.02% sodium azide,1% protective protein and 50% glycerol,pH7.4

Purification method:Antigen Affinity Purification

Dilution:WB 1:500-1:1000

Calculated MW:42 kDa

ObservedMW:42 kDa