ACO1 Polyclonal Antibody

SKU: E-AB-12938

Size::120μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:ACO1

Target Synonym:ACO 1;ACO1;ACOC;Aconitase 1 soluble;Aconitase;Aconitase1;Aconitate hydratase;ACONS;Citrate hydro lyase;Citrate hydro-lyase;Cytoplasmic aconitate hydratase;Ferritin repressor protein;IRE BP 1;IRE-BP 1;IREB 1;IREB1;IREBP;IREBP1;Iron regulatory protein 1;Iron responsive element binding protein 1;Iron-responsive element-binding protein 1;IRP 1;IRP1;OTTHUMP00000045233

Research Areas:Cancer;Cardiovascular;Epigenetics and Nuclear Signaling;Metabolism;Signal Transduction

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:IHC

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:P21399

Accession:

Background:Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.

Concentration:0.4 mg/mL

Immunogen:Synthetic peptide of human ACO1

Buffer:PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method:Affinity purification

Dilution:IHC 1:50-1:200

Calculated MW:

ObservedMW: