YWHAB Antibody - Cat. #: CSB-RA616077A0HU

SKU: CSB-RA616077A0HU

Size :50ul

Clone Number:6F6

Aliases:14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed], YWHAB

Product Type:Recombinant Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P31946

Immunogen:A synthesized peptide derived from human YWHAB

Raised in:

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB, IF, FC; Recommended dilution: WB:1:500-1:2000, IF:1:50-1:200, FC:1:50-1:200

Background:Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13. {ECO:0000269|PubMed:17717073, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21224381}.

Clonality:Monoclonal

Isotype:Rabbit IgG

Purification Method:Affinity-chromatography

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:YWHAB

Research Areas:Neuroscience; Cell biology; Signal transduction; Stem cells