XRCC4 Antibody - Cat. #: CSB-PA956465

SKU: CSB-PA956465

Size :100ul

Clone Number:

Aliases:DNA double strand break repair and V(D)J recombination protein XRCC4 antibody; DNA repair protein XRCC4 antibody; SSMED antibody; X ray repair complementing defective repair in Chinese hamster cells 4 antibody; X ray repair cross complementing 4 antibody; X ray repair cross complementing protein 4 antibody; X-ray repair cross-complementing protein 4 antibody; XRCC 4 antibody; XRCC4 antibody; XRCC4_HUMAN antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q13426

Immunogen:Synthesized peptide derived from Internal of Human XRCC4.

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB; WB:1:500-1:3000

Background:Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.

Ling Chen, J. Biol. Chem., Aug 2000; 275: 26196.
J

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:XRCC4

Research Areas:Epigenetics and Nuclear Signaling