X Antibody - Cat. #: CSB-PA355969LA01HEM

SKU: CSB-PA355969LA01HEM

Size :50ug

Clone Number:

Aliases:XProtein X antibody; HBx antibody; Peptide X antibody; pX antibody

Product Type:Polyclonal Antibody

Immunogen Species:Hepatitis B virus genotype D subtype ayw (isolate France/Tiollais/1979) (HBV-D)

UniProt ID:P03165

Immunogen:Recombinant Hepatitis B virus genotype D subtype ayw Protein X protein (1-154AA)

Raised in:Rabbit

Species Reactivity:Hepatitis B virus genotype D subtype ayw

Tested Applications:ELISA

Background:Multifunctional protein that may modulate protein degradation pathways, apoptosis, transcription, signal transduction, cell cycle progress, and genetic stability by directly or indirectly interacting with hosts factors. Does not seem to be essential for HBV infection. May be directly involved in development of cirrhosis and liver cancer (hepatocellular carcinoma). Most of cytosolic activities involve modulation of cytosolic calcium. The effect on apoptosis is controversial depending on the cell types in which the studies have been conducted. By binding to human DDB1, may affect cell viability and stimulate genome replication. May induce apoptosis by localizing in mitochondria and causing loss of mitochondrial membrane potential. May also modulate apoptosis by binding human CFLAR, a key regulator of the death-inducing signaling complex (DISC). Moderately stimulates transcription of many different viral and cellular transcription elements. Promoters and enhancers stimulated by HBx contain DNA binding sites for NF-kappa-B, AP-1, AP-2, c-EBP, ATF/CREB, or the calcium-activated factor NF-AT. May bind bZIP transcription factors like CREB1 (By similarity).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:X

Research Areas:Others