VPS11 antibody , Cat. # FNab09426

SKU: FNab09426

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations(PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes(PubMed:25783203). Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes(PubMed:21148287). Involved in the retrograde Shiga toxin transport(PubMed:23593995).

Immunogen:vacuolar protein sorting 11 homolog(S. cerevisiae)

Synonyms:END1, hVPS11, PEP5, RING finger protein 108, RNF108, VPS11

Observed MW:108 kDa

Uniprot ID:Q9H270

Reactivity:Human, Mouse, Rat

Tested Application:ELISA, WB, IF, FC, IP

Recommended dilution:WB: 1:500-1:5000; IF: 1:10-1:100; IP: 1:200-1:2000; FC:N/A

Gene ID:55823

Research Area:Signal Transduction