VHL Antibody - Cat. #: CSB-PA991849

SKU: CSB-PA991849

Size :50ul

Clone Number:

Aliases:Elongin binding protein antibody; G7 protein antibody; HRCA 1 antibody; HRCA1 antibody; Protein G7 antibody; pVHL antibody; RCA 1 antibody; RCA1 antibody; VHL 1 antibody; VHL antibody; VHL_HUMAN antibody; VHL1 antibody; VHLH antibody; Von Hippel Lindau antibody; Von Hippel Lindau disease tumor suppressor antibody; von Hippel Lindau syndrome antibody; von Hippel Lindau tumor suppressor antibody; Von Hippel Lindau tumor suppressor, E3 ubiquitin protein ligase antibody; Von Hippel-Lindau disease tumor suppressor antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P40337

Immunogen:Fusion protein of Human VHL

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; ELISA:1:2000-1:10000, IHC:1:50-1:200

Background:Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen affinity purification

Conjugate:Non-conjugated

Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:VHL

Research Areas:Epigenetics and Nuclear Signaling;Cancer;Cell biology;Metabolism