USP19 Antibody - Cat. #: CSB-PA173374

SKU: CSB-PA173374

Size :100ul

Clone Number:

Aliases:8430421I07Rik antibody; AI047774 antibody; Deubiquitinating enzyme 19 antibody; Ubiquitin carboxyl terminal hydrolase 19 antibody; Ubiquitin carboxyl-terminal hydrolase 19 antibody; Ubiquitin specific peptidase 19 antibody; Ubiquitin specific processing protease 19 antibody; Ubiquitin specific protease 19 antibody; Ubiquitin thioesterase 19 antibody; Ubiquitin thiolesterase 19 antibody; Ubiquitin-specific-processing protease 19 antibody; UBP19_HUMAN antibody; Usp19 antibody; Zinc finger MYND domain containing protein 9 antibody; Zinc finger MYND domain-containing protein 9 antibody; ZMYND9 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O94966

Immunogen:Synthesized peptide derived from internal of Human USP19.

Raised in:Rabbit

Species Reactivity:Human, Mouse

Tested Applications:ELISA, WB, IHC; WB:1:500-1:3000, IHC:1:50-1:100

Background:Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked Ubiquitin chains.

Nagase T., DNA Res. 5:355-364(1998).
The MGC Project Team, Genome Res. 14:2121-2127(2004).
Beausoleil S.A., Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:USP19

Research Areas:Epigenetics and Nuclear Signaling;Cell biology