USP14 antibody , Cat. # FNab09310

SKU: FNab09310

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation(ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions(NMJs).

Immunogen:ubiquitin specific peptidase 14(tRNA-guanine transglycosylase)

Synonyms:Deubiquitinating enzyme 14, TGT, Ubiquitin thiolesterase 14, USP14

Observed MW:52-60 kDa

Uniprot ID:P54578

Reactivity:Human, Mouse, Rat

Tested Application:ELISA, WB, IF, FC

Recommended dilution:WB: 1:500-1:5000; IP: 1:500-1:5000; IF: 1:10-1:100

Gene ID:9097

Research Area:Epigenetics, Metabolism