USP11 antibody , Cat. # FNab09306

SKU: FNab09306

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains(PubMed:12084015, PubMed:15314155, PubMed:17897950, PubMed:19874889, PubMed:20233726, PubMed:24724799). Inhibits the degradation of target proteins by the proteasome(PubMed:12084015). Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains(in vitro)(PubMed:24724799). Plays a role in the regulation of pathways leading to NF-kappa-B activation(PubMed:17897950, PubMed:19874889). Plays a role in the regulation of DNA repair after double-stranded DNA breaks(PubMed:15314155, PubMed:20233726).

Immunogen:ubiquitin specific peptidase 11

Synonyms:Deubiquitinating enzyme 11, Ubiquitin thiolesterase 11, UHX1, USP11

Observed MW:110 kDa

Uniprot ID:P51784

Reactivity:Human

Tested Application:ELISA, WB, IHC, IP

Recommended dilution:WB: 1:500-1:1000; IP: 1:200-1:1000; IHC: 1:50-1:500

Gene ID:8237

Research Area:Epigenetics, Metabolism