UPF2 Antibody - Cat. #: CSB-PA867186DSR2HU

SKU: CSB-PA867186DSR2HU

Size :50ul

Clone Number:

Aliases:DKFZp434D222 antibody; hUpf2 antibody; KIAA1408 antibody; MGC138834 antibody; MGC138835 antibody; Nonsense mRNA reducing factor 2 antibody; Regulator of nonsense transcripts 2 antibody; RENT2 antibody; RENT2_HUMAN antibody; Smg 3 antibody; Smg 3 homolog nonsense mediated mRNA decay factor antibody; Up-frameshift suppressor 2 homolog antibody; UPF2 antibody; UPF2 regulator of nonsense transcripts homolog antibody; UROC1 antibody; Urocanate hydratase antibody; Yeast Upf2p homolog antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9HAU5

Immunogen:Recombinant Human Regulator of nonsense transcripts 2 protein (1153-1272AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background:Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen Affinity Purified

Conjugate:Non-conjugated

Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:UPF2

Research Areas:Epigenetics and Nuclear Signaling