UMOD Polyclonal Antibody

SKU: D-AB-10364L

Size::25μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:UMOD

Target Synonym:ADMCKD2;FJHN;HNFJ;HNFJ1;MCKD2;medullary cystic kidney disease 2 (autosomal dominant);Tamm Horsfall glycoprotein;Tamm Horsfall urinary glycoprotein;Tamm-Horsfall urinary glycoprotein;THGP;THP;Umod;Urehd1;urehr4;UROM_HUMAN;uromodulin (uromucoid; Tamm-Horsfall glycoprotein); Uromodulin

Research Areas:Cancer;Cell Biology

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human

Application:IHC

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:P07911

Accession:

Background:The protein encoded by this gene is the most abundant protein in mammalian urine under physiological conditions. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. This protein may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of this protein in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the renal disorders medullary cystic kidney disease-2 (MCKD2), glomerulocystic kidney disease with hyperuricemia and isosthenuria (GCKDHI), and familial juvenile hyperuricemic nephropathy (FJHN). Alternative splicing of this gene results in multiple transcript variants.

Concentration:1 mg/mL

Immunogen:Recombinant Human UMOD protein expressed by E.coli

Buffer:PBS with 0.02% sodium azide,1% protective protein and 50% glycerol,pH7.4

Purification method:Antigen Affinity Purification

Dilution:IHC 1:100-1:200

Calculated MW:

ObservedMW: