TYRO3 Antibody, HRP conjugated - Cat. #: CSB-PA025396LB01HU

SKU: CSB-PA025396LB01HU

Size :50ug

Clone Number:

Aliases:Brt antibody; BYK antibody; DTK antibody; Etk-2 antibody; protein tyrosine kinase 3 antibody; Rek antibody; RSE antibody; SKY antibody; Tif antibody; tyro3 antibody; TYRO3 protein tyrosine kinase antibody; TYRO3_HUMAN antibody; Tyrosine-protein kinase byk antibody; Tyrosine-protein kinase DTK antibody; Tyrosine-protein kinase receptor TYRO3 antibody; Tyrosine-protein kinase RSE antibody; Tyrosine-protein kinase SKY antibody; Tyrosine-protein kinase TIF antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q06418

Immunogen:Recombinant Human Tyrosine-protein kinase receptor TYRO3 protein (728-873AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:HRP

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:TYRO3

Research Areas:Neuroscience; Signal transduction