TXNIP antibody , Cat. # FNab09129

SKU: FNab09129

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1(mTORC1).

Immunogen:thioredoxin interacting protein

Synonyms:EST01027, HHCPA78, THIF, Thioredoxin binding protein 2, TXNIP, VDUP1

Observed MW:50 kDa

Uniprot ID:Q9H3M7

Reactivity:Human, Mouse, Rat

Tested Application:ELISA, IHC, WB, IF

Recommended dilution:WB: 1:200-1:2000; IP: 1:200-1:2000; IHC: 1:50-1:500; IF: 1:10-1:100

Gene ID:10628

Research Area:Metabolism