TTI1 antibody , Cat. # FNab09093

SKU: FNab09093

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Regulator of the DNA damage response(DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase(PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation(IR), ultraviolet(UV) and mitomycin C(MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals.

Immunogen:KIAA0406

Synonyms:TELO2-interacting protein 1 homolog,KIAA0406, SMG10,TTI1

Observed MW:122 kDa

Uniprot ID:O43156

Reactivity:Human

Tested Application:ELISA, WB, IP

Recommended dilution:WB: 1:500-1:5000; IP: 1:500-1:5000

Gene ID:9675

Research Area: