TRPM8 Antibody - Cat. #: CSB-PA768757ESR1HU

SKU: CSB-PA768757ESR1HU

Size :50ul

Clone Number:

Aliases:Long transient receptor potential channel 6 antibody; LTrpC-6 antibody; LTrpC6 antibody; MGC2849 antibody; Short form of the TRPM8 cationic channel antibody; Transient receptor potential cation channel subfamily M member 8 antibody; Transient receptor potential p8 antibody; transient receptor potential-p8 antibody; Trp p8 antibody; Trp-p8 antibody; Trpm8 antibody; TRPM8_HUMAN antibody; TRPP8 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q7Z2W7

Immunogen:Recombinant Human Transient receptor potential cation channel subfamily M member 8 protein (980-1104AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background:Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity. Plays a role in prostate cancer cell migration (PubMed:25559186). Isoform 2 and isoform 3 negatively regulate menthol- and cold-induced channel activity by stabilizing the closed state of the channel.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen Affinity Purified

Conjugate:Non-conjugated

Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:TRPM8

Research Areas:Neuroscience; Cancer; Metabolism; Signal transduction