TNKS2 Antibody, FITC conjugated - Cat. #: CSB-PA867136LC01HU

SKU: CSB-PA867136LC01HU

Size :50ug

Clone Number:

Aliases:ADP-ribosyltransferase diphtheria toxin-like 6 antibody; ARTD6 antibody; PARP 5b antibody; PARP 5c antibody; PARP-5b antibody; PARP-5c antibody; PARP5B antibody; PARP5C antibody; pART6 antibody; Poly [ADP ribose] polymerase 5B antibody; Poly [ADP-ribose] polymerase 5B antibody; TANK2 antibody; Tankyrase 2 antibody; Tankyrase II antibody; Tankyrase like protein antibody; Tankyrase related protein antibody; Tankyrase TRF1 interacting ankyrin related ADP ribose polymerase 2 antibody; Tankyrase-2 antibody; Tankyrase-like protein antibody; Tankyrase-related protein antibody; TNKL antibody; TNKS 2 antibody; TNKS-2 antibody; TNKS2 antibody; TNKS2_HUMAN antibody; TRF1 Interacting Ankyrin Related ADP ribose polymerase 2 antibody; TRF1-interacting ankyrin-related ADP-ribose polymerase 2 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9H2K2

Immunogen:Recombinant Human Tankyrase-2 protein (1-246AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:

Background:Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. Stimulates 26S proteasome activity.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:FITC

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:TNKS2

Research Areas:Epigenetics and Nuclear Signaling; Signal transduction