TNF RI/TNFRSF1A Polyclonal Antibody

SKU: AN005930L

Size::25μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles. Protected from prolonged exposure to light.

Shipping:The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:TNF RI/TNFRSF1A

Target Synonym:CD120a;FPF;MS5;p55-R;p60;TBP1;TNFAR;TNFR1;TNFR1-d2;TNFR55;TNF-R55;TNFR60;TNF-R-I;TBP;TNFalpha-R;TNF-alphaR;TNFRp;TNFR1-d;FPF;MS5;p55;p55-R;p60;TBP1;TNFalpha-R1;TNF-alphaR1;TNFAR;Tnfr;TNF-R;TNF-R1;TNFR1-d2;TNFR55;TNF-R55;TNFR60;TNFRI;TNF-R-I;TNFRp55;Tnfr-1;Tnfr1;Tnfrsf1a;CD120a;TNFR-I; p55; TNFRSF1a

Research Areas:

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Rat

Application:WB

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:P25118

Accession:

Background:TNF-α is an important cytokine produced by numerous cell types, including neutrophils, activated lymphocytes, macrophages, and NK cells. It plays a critical role in inflammatory responses and apoptosis. TNF-α exists as a membrane-anchored and soluble form, both of which show biological activity. Response to TNF-α is mediated through two receptors, TNF-R1, which is widely expressed, and TNF-R2, which is expressed mainly in immune and endothelial cells. Antagonists to TNF-α have been validated as therapeutic targets for rheumatoid arthritis and other immune disorders. The two receptors for TNF-α, TNF-R1 (55 kDa) and TNF-R2 (75 kDa) can mediate distinct cellular responses. In most cases cytotoxicity elicited by TNF has been reported to act through TNF-R1. Cytotoxicity is mediated by a "death domain" with the intracellular region of the receptor that binds to the death domain adaptor protein TRADD and triggers the activation of caspases (8). Soluble forms of both receptors have also been characterized which can bind TNF-α and may play an important role in immune disorders.

Concentration:1 mg/mL

Immunogen:Recombinant Mouse TNF RI/TNFRSF1A protein expressed by E.coli

Buffer:PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4

Purification method:Antigen Affinity Purification

Dilution:WB 1:500-1:1000

Calculated MW:50 kDa

ObservedMW:50 kDa