TMED10 Antibody - Cat. #: CSB-PA023655ESR2HU

SKU: CSB-PA023655ESR2HU

Size :50ul

Clone Number:

Aliases:1110014C03Rik antibody; 21 kDa transmembrane trafficking protein antibody; 21 kDa transmembrane-trafficking protein antibody; MGC102351 antibody; p23 antibody; p24 family protein delta 1 antibody; p24 family protein delta-1 antibody; p24(DELTA) antibody; p24delta antibody; p24delta1 antibody; S31I125 antibody; S31III125 antibody; TMED 10 antibody; Tmed10 antibody; TMEDA_HUMAN antibody; Tmp 21 I antibody; Tmp 21 antibody; Tmp 21 I antibody; Tmp-21-I antibody; Transmembrane emp24 domain containing protein 10 antibody; Transmembrane emp24 domain-containing protein 10 antibody; Transmembrane emp24-like trafficking protein 10 (yeast) antibody; Transmembrane protein Tmp21 antibody; Transmembrane trafficking protein 21kD antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P49755

Immunogen:Recombinant Human Transmembrane emp24 domain-containing protein 10 protein (35-190AA)

Raised in:Rabbit

Species Reactivity:Human, Mouse

Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200

Background:Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1 (By similarity). In COPI vesicle-mediated retrograde transport involved in the biogenesis of COPI vesicles and vesicle coat recruitment. On Golgi membranes, acts as primary receptor for ARF1-GDP which is involved in COPI-vesicle formation. Increases coatomer-dependent GTPase-activating activity of ARFGAP2. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2LR1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Involved in trafficking of amyloid beta A4 protein and soluble APP-beta release (independent of modulation of gamma-secretase activity). As part of the presenilin-dependent gamma-secretase complex regulates gamma-cleavages of the amyloid beta A4 protein to yield amyloid-beta 40 (Abeta40). Involved in organization of the Golgi apparatus.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen Affinity Purified

Conjugate:Non-conjugated

Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:TMED10

Research Areas:Neuroscience; Signal transduction