TCF7L2 antibody , Cat. # FNab08556

SKU: FNab08556

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.

Immunogen:transcription factor 7-like 2(T-cell specific, HMG-box)

Synonyms:TCF4

Observed MW:68 kDa

Uniprot ID:Q9NQB0

Reactivity:Human, Mouse, Rat

Tested Application:ELISA, WB, IP

Recommended dilution:WB: 1:500-1:2000; IP: 1:200-1:2000

Gene ID:6934

Research Area:Metabolism, Developmental biology