TCF7 Monoclonal Antibody

SKU: BT-MCA3117

Size:100μL

Background:This gene encodes a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators. This gene is expressed predominantly in T-cells and plays a critical role in natural killer cell and innate lymphoid cell development. The encoded protein forms a complex with beta-catenin and activates transcription through a Wnt/beta-catenin signaling pathway. Mice with a knockout of this gene are viable and fertile, but display a block in T-lymphocyte differentiation. Alternative splicing results in multiple transcript variants. Naturally-occurring isoforms lacking the N-terminal beta-catenin interaction domain may act as dominant negative regulators of Wnt signaling.

Research_area:Epigenetics and Nuclear Signaling

Target_protein:TCF7

applications:IHC, ICC, FCM

Reactivity:Human

Clonality:Monoclonal

Clone ID:1B4E9

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:TCF7

Immunogen:Purified recombinant fragment of human TCF7 (AA: 168-358) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):41.6kDa

UniProt accession:P36402

Synonyms:TCF-1

GeneID:6932