STUB1 Antibody, HRP conjugated - Cat. #: CSB-PA892480LB01HU

SKU: CSB-PA892480LB01HU

Size :50ug

Clone Number:

Aliases:Antigen NY CO 7 antibody; Antigen NY-CO-7 antibody; C terminus of Hsp70-interacting protein antibody; Carboxy terminus of Hsp70 interacting protein antibody; Carboxy terminus of Hsp70-interacting protein antibody; Carboxy terminus of Hsp70p interacting protein antibody; CHIP antibody; CHIP_HUMAN antibody; CLL associated antigen KW 8 antibody; CLL-associated antigen KW-8 antibody; E3 ubiquitin protein ligase CHIP antibody; E3 ubiquitin-protein ligase CHIP antibody; Heat shock protein A binding protein 2 (c terminal) antibody; HSPABP2 antibody; NY CO 7 antibody; PP1131 antibody; SDCCAG7 antibody; Serologically defined colon cancer antigen 7 antibody; STIP1 homology and U Box containing protein 1 antibody; STIP1 homology and U box containing protein 1 E3 ubiquitin protein ligase antibody; STIP1 homology and U box-containing protein 1 antibody; STUB 1 antibody; STUB1 antibody; UBOX 1 antibody; UBOX1 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9UNE7

Immunogen:Recombinant Human E3 ubiquitin-protein ligase CHIP protein (1-48AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at \'Lys-41\', \'Lys-61\' and \'Lys-81\', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4. Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation. Negatively regulates the suppressive function of regulatory T-cells (Treg) during inflammation by mediating the ubiquitination and degradation of FOXP3 in a HSPA1A/B-dependent manner (PubMed:23973223).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:HRP

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:STUB1

Research Areas:Epigenetics and Nuclear Signaling; Signal transduction