Stat5 Monoclonal Antibody

SKU: BT-MCA3219

Size:100μL

Background:The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene.

Research_area:Others

Target_protein:Stat5

applications:FCM

Reactivity:Human

Clonality:Monoclonal

Clone ID:7F7A4

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:Stat5

Immunogen:Synthesized peptide of human Stat5 (AA: KAVDG[pTyr]VKPQIK).

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide.

Concentration:

Molecular weight(Da):90.6kDa

UniProt accession:P42229

Synonyms:MGF, STAT5A

GeneID:6776