SRRT Antibody - Cat. #: CSB-PA880129ESR1HU

SKU: CSB-PA880129ESR1HU

Size :50ul

Clone Number:

Aliases:ARS2 protein antibody; Arsenate resistance protein ARS2 antibody; Arsenite resistance protein 2 antibody; Arsenite resistance protein antibody; Arsenite-resistance protein 2 antibody; ASR2 antibody; MGC126427 antibody; Serrate antibody; Serrate RNA effector molecule antibody; Serrate RNA effector molecule homolog (Arabidopsis) antibody; Serrate RNA effector molecule homolog antibody; SRRT antibody; SRRT_HUMAN antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9BXP5

Immunogen:Recombinant Human Serrate RNA effector molecule homolog protein (627-876AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background:Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity).

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen Affinity Purified

Conjugate:Non-conjugated

Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:SRRT

Research Areas:Cell biology; Metabolism; Signal transduction