SPOP Polyclonal Antibody

SKU: BT-AP08515

Size:100μL

Background:SPOP (speckle type BTB/POZ protein) encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1. , a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of SPOP results in multiple transcript variants encoding the same protein.

Research_area:Epigenetics and Nuclear Signaling

Target_protein:SPOP

applications:WB, ELISA

Reactivity:Human, Mouse, Rat

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:SPOP Antibody

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):42132

UniProt accession:Human: O43791; Mouse: Q6ZWS8

Synonyms:Speckle-type POZ protein (HIB homolog 1) (Roadkill homolog 1)

GeneID:Human: 8405; Mouse: 20747