SPIN1 Antibody - Cat. #: CSB-PA548594

SKU: CSB-PA548594

Size :100ul

Clone Number:

Aliases:OCR antibody; Ovarian cancer-related protein antibody; SPIN antibody; Spin1 antibody; SPIN1_HUMAN antibody; Spindlin-1 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9Y657

Immunogen:Synthesized peptide derived from internal of Human SPIN1.

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB; WB:1:500-1:3000

Background:Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway dowstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (). May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption.

Zhang H.L., Chin. Sci. Bull. 45:909-914(2000).
Gao Y., Biochem. Biophys. Res. Commun. 335:343-350(2005).
Humphray S.J., Nature 429:369-374(2004).

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:SPIN1

Research Areas:Epigenetics and Nuclear Signaling;Cancer;Cell biology?Developmental biology