SNAI2 Monoclonal Antibody

SKU: BT-MCA4755

Size:100μL

Background:This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity.The tumor suppressor protein p53 induces Slug expression in gamma-irradiated cells; Slug protects damaged cells from apoptosis by repressing p53-induced transcription of the proapoptotic Bcl-2 family protein Puma. Mutations in this gene may be associated with sporatic cases of neural tube defects.

Research_area:Neuroscience, Cancer, Stem cells, Epigenetics and nuclear signaling, Developmental biology

Target_protein:SNAI2

applications:

Reactivity:Human

Clonality:Monoclonal

Clone ID:2H5

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:SNAI2

Immunogen:Purified recombinant fragment of human SNAI2 expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):30kDa

UniProt accession:O43623

Synonyms:SLUG, WS2D, SLUGH1, MGC10182, SNAI2

GeneID:6591